San Francisco 49ers: Full Win/Loss Predictions for All 16 Games
By Bobby Horne
![January 20, 2016; Santa Clara, CA, USA; Chip Kelly poses for a photo after being introduced as the new head coach for the San Francisco 49ers at Levi's Stadium Auditorium. Mandatory Credit: Kyle Terada-USA TODAY Sports January 20, 2016; Santa Clara, CA, USA; Chip Kelly poses for a photo after being introduced as the new head coach for the San Francisco 49ers at Levi's Stadium Auditorium. Mandatory Credit: Kyle Terada-USA TODAY Sports](https://images2.minutemediacdn.com/image/upload/c_fill,w_720,ar_16:9,f_auto,q_auto,g_auto/shape/cover/sport/d36b862e915873853b39e520656e271128e9fd01749dc5bdb978c3c260199557.jpg)
Week 5
When: Thursday, October 6th
Who: Arizona Cardinals
Where: Levi’s Stadium
The second and final prime-time game of the season comes against a very good Cardinals team. Once again, the 49ers are faced with an extremely tough matchup against a Super Bowl-ready team. This will not be a fun night for the 49ers.
Key Matchup: Colin Kaepernick vs. Cardinals Secondary
After throwing 4 interceptions the last time Kaepernick played against the Cardinals, he will look for some revenge. He won’t find any on this night, but it will still be a matchup to watch.
Prediction: Loss
Next: Week 6